Genomics and Proteomics (BT504)

1. In Lander and Waterman model, if overlap length was larger than a cutoff (T), then the two reads should be merged into a ________.

   1. Contig
   2. Assembly
   3. Scaffold
   4. Graph

2. The first step of the De Bruijn assembler is to ________ the sequencing reads into its constitutive "kmers".

   1. Deconstruct
   2. Reconstruct
   3. Construct
   4. Arrange

3. The terms "proteomics" and "proteome" were coined by Marc Wilkins and Colleagues in ________.

   1. 1994
   2. 1990
   3. 1984
   4. 2003

4. The nuclear genome of yeast consists of ________ chromosomes.

   1. 16
   2. 10
   3. 32
   4. 2

5. Protein forming amino acids are called ________ amino acids.

   1. Essential
   2. Non-essential
   3. Basic
   4. Standard

6. Which of the following statements regarding the peptide bond is false?

   1. The peptide is rigid and planar.
   2. The oxygen atom of the carbonyl carbon and the hydrogen atom of the amide group lie in a cis position relative to each other.
   3. The carbon nitrogen bond in a peptide linkage is shorter than the normal carbon nitrogen bond in an amine.
   4. The carbon nitrogen bond in the peptide linkage has a partial double bond character.

7. Structural Genomics incudes except ________.

   1. Abundance and complexity of mRNA
   2. Gene phylogeny
   3. Genome sequences
   4. Distinct components of genomes

8. In an overlap graph, an ________ connects two nodes if an overlap is identified between the corresponding reads.

   1. Vertex
   2. Edge
   3. Node
   4. Arc

9. Proteins are biological important except ________.

   1. Cellular Function
   2. Structural importance
   3. Enzymes
   4. 1st choice Energy Source

10. In Assembly Pipeline Quality Screening is done while satisfying the following matrices, except ________.

    1. Poisson distribution
    2. Library quality
    3. Sequencing Run Quality
    4. Read Quality

11. In genome assembly Short dead-end branches of the main path are called ________.

    1. Spurs
    2. Bubbles
    3. Converging and diverging paths
    4. Cycles

12. The proteome is ________ the genome due to alternative splicing.

    1. Larger than
    2. Smaller than
    3. Proportional to
    4. Equal to

13. Linus Pauling and Robert Corey carefully analyzed the ________ bond.

    1. Peptide
    2. Glyosidic
    3. Phosphodiester
    4. Hydrogen

14. Protein Domain comparison reveals the ________ of the Proteome.

    1. Biological roles
    2. Physical roles
    3. Organic roles
    4. Chemical roles

15. ALLPATHS-LG requires ________ computer operating system.

    1. 64 bit Linux
    2. 32 bit Linux
    3. 64 bit Windows
    4. 32 bit Windows

16. ________ are non-homologues genes/proteins that have descended convergently from an unrelated ancestor.

    1. Analogues
    2. Paralogues
    3. Orthologues
    4. Xenologues

17. The qualities of genome assemblies are evaluated by ________.

    1. Presence of expected genes
    2. Poisson distribution
    3. Presence of expected introns
    4. Presence of expected exons

18. We sequence genomes for the understanding mechanism of diseases except ________.

    1. Metabolic diseases
    2. Infectious diseases
    3. Pathogenic bacteria
    4. Inherited diseases

19. Within each domain there is no systematic relationship between genome size and ________.

    1. SNP
    2. RFLP
    3. Phenotype
    4. Genotype

20. The local conformation of a part of a polypeptide chain within a protein is known as ________ structure.

    1. quaternary
    2. tertiary
    3. secondary
    4. primary

21. Most common measure of assembly quality is ________.

    1. N50
    2. N95
    3. M50
    4. KN95

22. We can predict disease-susceptibility based on gene sequence ________.

    1. Duplication
    2. Alignment
    3. Variation
    4. Distribution

23. Genetic map of the human genome has 24 different maps: one for each ________, X and Y chromosome

    1. Pair of chromosomes
    2. Chromatid
    3. Chromatin
    4. Autosome

24. the size of haploid yeast genome is ________ Mb

    1. 12.1
    2. 11.3
    3. 16
    4. 13.2

25. Population Genomics is study of all these except ________.

    1. Study about the genetic diversity
    2. Comparison of gene numbers
    3. Understanding new insights into disease and drug response
    4. Study of genomes of a specific population

26. ________ proteomics refers to the quantitative study of protein expressionbetween samples differing by some variable.

    1. Expression
    2. Functional
    3. Structural
    4. Protein Profiling

27. ALLPATHS-LG assemblies are not necessarily ________, but instead are presented in the form of a ________.

    1. Linear, graph
    2. Circular, graph
    3. Graph, Line
    4. Linear, Circle

28. Graph is a set of nodes plus set of edges between the ________.

    1. Nodes
    2. Edges
    3. Nodes and edges
    4. Arc

29. Human Mitochondrial Genome is ________ and double stranded.

    1. Conjugated
    2. Linear
    3. Circular
    4. Nuclear

30. Self-comparison of proteome yields ________ and duplications.

    1. Gene families
    2. Protein families
    3. Proteome families
    4. Genome families

31. For genome assembly try different assemblers as there is no ________.

    1. Best assembler
    2. Duplicates
    3. Libraries
    4. Parameter

32. Study of Proteomics is important except ________.

    1. It directly contributes to drug development
    2. Classification of a gene product
    3. Modifications of the proteins
    4. Protein expression

33. Assembly Pipeline process can be divided into following major phases, except ________.

    1. Assembling
    2. Unitiging
    3. Scaffolding
    4. Repeat resolution

Select a course code for Objective Questions:

ACC311 ACC501 BIF101 BIF401 BIF501 BIO101 BIO201 BIO202 BIO203 BIO204 BIO301 BIO302 BIO303 BIO401 BIO503 BNK603 BT101 BT201 BT301 BT302 BT401 BT402 BT403 BT404 BT405 BT406 BT501 BT504 BT505 BT604 CHE201 CHE301 CS001 CS101 CS201 CS202 CS204 CS301 CS302 CS304 CS311 CS401 CS402 CS403 CS408 CS501 CS502 CS504 CS506 CS508 CS601 CS602 CS604 CS605 CS607 CS609 CS610 CS614 CS707 CS710 ECO401 ECO402 ECO403 ECO404 EDU302 EDU401 EDU402 EDU501 EDU601 ENG101 ENG201 ENG301 ENG501 FIN611 FIN624 FIN625 ISL201 IT430 MCM101 MCM301 MGMT623 MGT101 MGT211 MGT301 MGT401 MGT402 MGT501 MGT502 MGT503 MGT510 MGT601 MGT603 MKT501 MKT610 MKT630 MTH101 MTH202 MTH302 MTH501 MTH601 MTH634 PAK301 PHY101 PHY301 PSY101 PSY403 PSY502 PSY512 SOC101 SOC301 SOC401 STA301 STA630 STA641 ZOO102 ZOO401 ZOO501 ZOO502 ZOO503 ZOO504 ZOO505 ZOO506 ZOO510 ZOO630

Select a course code for Subjective Questions:

ACC311 CS001 CS101 CS201 CS301 CS607 CS701 CS702 CS703 CS704 CS707 CS708 CS710 CS711 CS718 CS721 CS724 ECO401 ECO403 ENG101 ENG301 MGT703 MTH501 STA301