Multiple Choice Questions (MCQs)
When DNA is heated, the temperature at which ________ of the helical structure is lost is defined as the melting temperature.
The DNA oligonucleotide abbreviated pATCGAC:
Purine base found in RNA is
single-stranded DNA has a ________ relative absorbance at 260nm wavelength than does double-stranded DNA.
A phosphodiester bond is present in
Disruption of DNA can occur in the laboratory with alteration in
DNA model was presented by Watson and Crick in ________.
Nucleotides are composed of
The sugar molecule present in nucleotide is
Certain anticancer drugs, exert their cytotoxic effect by intercalating into the ________ groove of the DNA double helix, thus interfering with RNA and DNA synthesis
DNA that is not copied during the synthesis of mRNA is also called as
A short length of DNA molecule has 80 thymine and 80 guanine bases. The total number of nucleotide in the DNA fragment is
Which one of the following is true of the pentoses found in nucleic acids?
Chromatin is composed of
Z-DNA have a
The DNA wrapped around the nucleosome core is continuous and joins one nucleosome core to the next -the linker DNA this 50 bp DNA is complexed with the fifth type of histone. ________
Nucleoside contains
According to Chargaff's Rules which one is not correct
These ________ bonds, plus the van der Waals and hydrophobic interactions between the adjacent stacked bases, stabilize the structure of the double helix.
Any regular, stable structure taken up by some or all of the nucleotides in a nucleic acid can be referred to as
histones are ________ charged
Nucleosomes can be packed more tightly to form a polynucleosome also called a nucleofilament or a ________nm fiber.
The difference between thymine and uracil is:
Nucleic acids are a polymer of nucleotide monomeric units. Each nucleotide consists of
ATP is a
Which one is example of coenzymes
Under appropriate conditions DNA will form a hybrid with a complementary ________.
In living cells, nucleotides and their derivatives can serve as:
Separation of the two strands of the double helix when ________ bonds between the paired bases are disrupted.
A DNA segment contains 100 Adenine and 100 cytosines, how many nucleotides are present in the segment?
The Tm of DNA is influenced by
Around structural core of the nucleosome, a segment of the DNA double helix is wound nearly twice-approximately ________.
In a double-stranded nucleic acid, cytosine typically base-pairs with:
The complex folding of large chromosomes within eukaryotic chromatin and bacterial nucleoids is generally considered ________.
S-adenosylmethionine is a ________ group donor.
The "energy carrier" ATP is an example of a(n):
higher GC base pairs increases Tm, because, with three hydrogen bonds, require ________ heat energy to dissociate than AT base pairs.
Find the correct statement about phosphodiester linkage between adjacent nucleotides in nucleic acids
RNA duplexes are ________ stable than DNA duplexes.
There are ________ classes of histones
Which of the following is a palindromic sequence?
Eukaryotic DNA is associated with tightly bound basic ________, called histones.
The phosphodiester bonds that link adjacent nucleotides in both RNA and DNA:
When linked to vitamins nucleotides are structural components of several essential coenzymes, for example,
Compounds that generate nitrous acid (such as nitrites, nitrates, and nitrosamines) change DNA molecules by:
The ________ strand is called Template strand while
DNA replication is
Nucleotides also serve as carriers of activated intermediates in the synthesis of ________.
Adenosine 3'-phosphate-5'-phosphosulfate is the ________ donor.
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