Multiple Choice Questions (MCQs)
The secondary structure of a protein consists of all but one of the following, which is odd one out?
The Phi and Psi values of a Beta-strand composed of all D-amino acids will mainly occupy which quadrant in the Ramachandran plot?
Which of the following is not protein fragmentation technique.
rRNA is synthesized by:
Block analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.
Bioinformatics can deliver:
In GenBank, specific gene can be searched by using?
DNA makes RNA and RNA makes protein, this process is termed as
Which of the following is the correct order of organization of genetic material from largest to smallest?
In Corey-Paulin-Koltun Diagram, each atom is represented by ________.
Which of the following is the character based phylogenetic tree construction methods?
The scoring of gaps in a MSA (Multiple Sequence Alignment) has to be performed in a different manner from scoring gaps in a pair-wise alignment?
In the alpha helix the hydrogen bond:
Balls and sticks are solid spheres and rods, representing atoms and bond, respectively.
Which of these bonds is not involved in forming the secondary structure of a protein?
Visualization methods are very important in viewing molecular properties on molecules. Of particular note is the rendering of molecular surfaces according to their various properties (that can be expressed numerically).
Black analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.
An alpha helix is formed by hydrogen bonding between the hydrogen of an amine group and the backbone carbonyl group how many amino acids upstream of it?
The basic idea of thermodynamic stability is to maximize bonding in order to minimize the free energy.
The greater the number of bonds between the amino acids, the ________ stable a protein becomes.
Translation is the process in which
Choose the incorrect statement out of the following?
BLASTX uses protein sequences as queries to search against a protein sequence database.
GeneBank and UniPort have
The interactions which holds and stabilizes the sub-units in 4' structure of proteins are:
The procedure of aligning two sequences by searching of patterns that is in the same order in the sequences?
Which of the following doesn't describe PAM matrices?
Messenger RNA is
Which of the following is not a benefit or a factual of FASTA over BLAST?
Beeta-pleated sheets are the examples of ________.
Your lab partner is using BLAST, and his best E-value is 3. This means that
The putative ORF can be translated into a protein sequence, which is then used to search against a protein database.
The identification of drugs through genomic study is known as
The Alignment method suitable for finding out conserved patterns in DNA or Protein sequences is
X-Ray data need a minimum of ________ resolution.
Who discovered diffraction pattern for DNA?
In multiple sequence alignment (MSA), we have ________ .
Mfold gives out (output) several structures along with their ________.
Which of the following is not a variant of BLAST?
mRNA directs the building of proteins through a sequence of
Which of the following statements about amino acids is correct?
Which of the following is untrue about the Unweighted Pair Group Method Using Arithmetic Average?
If two atoms are participating in a covalent bond, their distance will be equal to?
Which of the following is untrue anout the modification of PAM matrices?
Which of the following is the smallest of the RNAs?
How many proteins does the human body produce?
The ________ tool compares nucleotide sequence against DNA database.
How many types of secondary structures can be formed possibly by folding of RNA?
Analyzing or comparing entire genome of species known as,
Zuker's Algorithm involves energy ________.
FASTA format start with ________ symbol.
X-ray diffraction data helps measure ________.
The BLAST program was developed in ________ .
Bioinformatics is the interdisciplinary relative new development of ________.
A Protein Data Bank (PDB) data file for a protein structure contains only x and y coordinates of atoms.
Which of the following is not an ionization techniques in proteins?
GenBank and SWISSPORT are example of
GenBank database is maintained by ________.
Which one of the following is not a tool for protein visualization?
Elongation of transcription and RNA processing are all interconnected?
Amino acids are mostly synthesized from
The correct order of progressive alignment steps for multiple sequence alignment is ________ .
Messenger RNA is only ________ of RNA content in the cell.
In a similar way to structure prediction methods can be evaluated using RMSD to measure the similarity between two molecular complexes.
For which one of the following activities, bioinformatics is used in modern biological sciences?
Unfolding of a protein can be termed as ________.
Which one of the following are Archaea?
All of the following are protein sequence database, except ________.
All of the following are protein sequence databases except ________.
In Bottom up proteomics, Enzyme ________ is used to cleave the proteins.
CLUSTALW is a more recent version of CLUSTAL with the W standing for ________.
All are nucleotide sequence database, except
RNA is the genetic material in
There are 64 codons in the genetic dictionary as:
________ compares protein sequence against protein databases.
Amino acids are joined together to form polypeptides. Each amino acid is attached to another by a peptide bond. What functional group is created when amino acids are joined together?
To determine the number of each type of interaction within a protein, we need to find its inter atomic distances.
Which of the following doesn't describe local alignment?
In multiple sequence alignment ________ .
What is the source of protein structures in SCOP and CATH?
Sum of stabilizing and destabilizing energies can help determine the ________.
Which is the default scoring matrix used in BLAST?
Addition or removal of amino acids from protein sequences or nucleotides from DNA or RNA sequences is known as?
Alpha helices and beta sheets are formed because of ________.
The peptide bond in protein is:
X-Ray Crystallography data shows that hydrogen atoms of N-Term may come together with Oxygen atoms of C-term amino acid at ________ position.
Which one of the following types of bond is principally responsible for holding the α-helix shape of a protein secondary structure?
Which one of the following is not a "Sequence Alignment Tool"?
Ribbon diagram use cylinders or spiral ribbons to represent alpha-helices and broad, flat arrows to represent beeta-strands.
Which of the following methods are broad class of computational algorithms that rely on repeated random sampling to obtain numerical results.
Dot plot of repeating elements would be small crosses on plot.
Nussinov-Jacobson (NJ) Algorithm is a dynamic Programming (DP) strategy to predict ________.
The major element of secondary structure in myoglobin and hemoglobin is:
Which one of the following issues are addressed by using computational methods, data processing techniques and algorithms?
Dynamic Programming uses a "________" to deal with matches, mismatches and gaps.
What are 2 things required in order to successfully use the dynamic programming technique?
The ________ E-Value, the more significant the hit.
Which of the following is not a benefit of BLAST?
________ are the units of proteins.
Laboratory work using computers and computer-generated models generally offline is referred as:
Progressive alignment methods use the dynamic programming method to build a MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment?
Name any two frequently used scoring matrices
74- Scoring Matrices contains,
Which one of the following methods can be used for statistical evaluation of data?
C-Alpha atoms are traced to recreate the ________ protein structure.
The first RNA processing event is
Alpha Helices are formed by hydrogen bonding between ________ and ________ atoms in the protein backbone?
Amino acids are chained together by ________.
RNA is found in the nucleolus of the cell and DNA is found in
The study of full complement of proteins expressed by a genome is called
Which algorithm is used by global alignment?
Beta Sheets are secondary structure that can be formed as a result of ________.
Single letter code of Tyrosine is ________.
In dynamic programming we can do multiple sequence alignment upto ________
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