Multiple Choice Questions (MCQs)
In Corey-Paulin-Koltun Diagram, each atom is represented by ________.
To determine the number of each type of interaction within a protein, we need to find its inter atomic distances.
All of the following are protein sequence databases except ________.
Beeta-pleated sheets are the examples of ________.
Addition or removal of amino acids from protein sequences or nucleotides from DNA or RNA sequences is known as?
GenBank and SWISSPORT are example of
Which of the following is not a benefit or a factual of FASTA over BLAST?
FASTA format start with ________ symbol.
Single letter code of Tyrosine is ________.
CLUSTALW is a more recent version of CLUSTAL with the W standing for ________.
Choose the incorrect statement out of the following?
________ are the units of proteins.
Unfolding of a protein can be termed as ________.
Translation is the process in which
The ________ tool compares nucleotide sequence against DNA database.
mRNA directs the building of proteins through a sequence of
The Phi and Psi values of a Beta-strand composed of all D-amino acids will mainly occupy which quadrant in the Ramachandran plot?
In the alpha helix the hydrogen bond:
Which of the following is untrue anout the modification of PAM matrices?
The major element of secondary structure in myoglobin and hemoglobin is:
Elongation of transcription and RNA processing are all interconnected?
Which of the following is not protein fragmentation technique.
DNA makes RNA and RNA makes protein, this process is termed as
Which one of the following is not a "Sequence Alignment Tool"?
________ compares protein sequence against protein databases.
Which of the following doesn't describe local alignment?
RNA is found in the nucleolus of the cell and DNA is found in
All are nucleotide sequence database, except
If two atoms are participating in a covalent bond, their distance will be equal to?
rRNA is synthesized by:
Which one of the following are Archaea?
Zuker's Algorithm involves energy ________.
X-Ray data need a minimum of ________ resolution.
In Bottom up proteomics, Enzyme ________ is used to cleave the proteins.
Which of the following is not an ionization techniques in proteins?
The study of full complement of proteins expressed by a genome is called
X-Ray Crystallography data shows that hydrogen atoms of N-Term may come together with Oxygen atoms of C-term amino acid at ________ position.
Which one of the following types of bond is principally responsible for holding the α-helix shape of a protein secondary structure?
Alpha helices and beta sheets are formed because of ________.
The first RNA processing event is
Your lab partner is using BLAST, and his best E-value is 3. This means that
Which of the following is the smallest of the RNAs?
Which of the following is the correct order of organization of genetic material from largest to smallest?
74- Scoring Matrices contains,
The procedure of aligning two sequences by searching of patterns that is in the same order in the sequences?
Black analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.
Visualization methods are very important in viewing molecular properties on molecules. Of particular note is the rendering of molecular surfaces according to their various properties (that can be expressed numerically).
In GenBank, specific gene can be searched by using?
Nussinov-Jacobson (NJ) Algorithm is a dynamic Programming (DP) strategy to predict ________.
A Protein Data Bank (PDB) data file for a protein structure contains only x and y coordinates of atoms.
The ________ E-Value, the more significant the hit.
There are 64 codons in the genetic dictionary as:
Messenger RNA is
Block analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.
The putative ORF can be translated into a protein sequence, which is then used to search against a protein database.
Bioinformatics is the interdisciplinary relative new development of ________.
The Alignment method suitable for finding out conserved patterns in DNA or Protein sequences is
Laboratory work using computers and computer-generated models generally offline is referred as:
How many types of secondary structures can be formed possibly by folding of RNA?
Alpha Helices are formed by hydrogen bonding between ________ and ________ atoms in the protein backbone?
Which of the following is not a variant of BLAST?
RNA is the genetic material in
The BLAST program was developed in ________ .
Amino acids are chained together by ________.
An alpha helix is formed by hydrogen bonding between the hydrogen of an amine group and the backbone carbonyl group how many amino acids upstream of it?
Mfold gives out (output) several structures along with their ________.
Which of these bonds is not involved in forming the secondary structure of a protein?
Who discovered diffraction pattern for DNA?
The scoring of gaps in a MSA (Multiple Sequence Alignment) has to be performed in a different manner from scoring gaps in a pair-wise alignment?
Which of the following doesn't describe PAM matrices?
Balls and sticks are solid spheres and rods, representing atoms and bond, respectively.
Sum of stabilizing and destabilizing energies can help determine the ________.
Dynamic Programming uses a "________" to deal with matches, mismatches and gaps.
Dot plot of repeating elements would be small crosses on plot.
Which of the following statements about amino acids is correct?
Analyzing or comparing entire genome of species known as,
Which algorithm is used by global alignment?
Which of the following methods are broad class of computational algorithms that rely on repeated random sampling to obtain numerical results.
The interactions which holds and stabilizes the sub-units in 4' structure of proteins are:
Which of the following is the character based phylogenetic tree construction methods?
In multiple sequence alignment ________ .
C-Alpha atoms are traced to recreate the ________ protein structure.
GeneBank and UniPort have
Which one of the following methods can be used for statistical evaluation of data?
Beta Sheets are secondary structure that can be formed as a result of ________.
GenBank database is maintained by ________.
Bioinformatics can deliver:
The correct order of progressive alignment steps for multiple sequence alignment is ________ .
X-ray diffraction data helps measure ________.
BLASTX uses protein sequences as queries to search against a protein sequence database.
The peptide bond in protein is:
What is the source of protein structures in SCOP and CATH?
The identification of drugs through genomic study is known as
All of the following are protein sequence database, except ________.
For which one of the following activities, bioinformatics is used in modern biological sciences?
The basic idea of thermodynamic stability is to maximize bonding in order to minimize the free energy.
Progressive alignment methods use the dynamic programming method to build a MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment?
Which one of the following is not a tool for protein visualization?
How many proteins does the human body produce?
Which one of the following issues are addressed by using computational methods, data processing techniques and algorithms?
Messenger RNA is only ________ of RNA content in the cell.
Which of the following is untrue about the Unweighted Pair Group Method Using Arithmetic Average?
The secondary structure of a protein consists of all but one of the following, which is odd one out?
Amino acids are joined together to form polypeptides. Each amino acid is attached to another by a peptide bond. What functional group is created when amino acids are joined together?
The greater the number of bonds between the amino acids, the ________ stable a protein becomes.
Ribbon diagram use cylinders or spiral ribbons to represent alpha-helices and broad, flat arrows to represent beeta-strands.
Amino acids are mostly synthesized from
Which of the following is not a benefit of BLAST?
In dynamic programming we can do multiple sequence alignment upto ________
In a similar way to structure prediction methods can be evaluated using RMSD to measure the similarity between two molecular complexes.
In multiple sequence alignment (MSA), we have ________ .
Which is the default scoring matrix used in BLAST?
What are 2 things required in order to successfully use the dynamic programming technique?
Name any two frequently used scoring matrices
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